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What people say makes us excited::
The graviola, a tree growing in the Amazon River basin, has shown great promise as a cancer treatment, as its extracts are extremely effective at finding and killing cancer cells up to 10,000 better than regular chemotherapy. As well, its bark, fruit, and leaves are used as antidepressants, painkillers, antiparasitics, antifungals, and a host of other uses.
Related articles on this topic are also available on the NewsTarget Network, including: Cancer Industry Spreads Fear and Disinformation To Scare People Away From Learning About Alternative Treatments for Cancer on the Internet.
Page 288
GRAVIOLA |
Family: Annonaceae
Genus: Annona Species: muricata Common Names: graviola, soursop, guanabana, guanabano, guanavana, guanaba, corossol epineux, huanaba, toge-banreisi, durian benggala, nangka blanda, cachiman epineux Parts Used: leaves, fruit, seeds, bark, roots
Over the last several years, graviola has become a popular complementary supplement for cancer.
In test tube studies graviola has shown to be toxic to many types of cancer cells including lung, prostate, colon, breast, liver, pancreas, ovarian, skin, cervical, skin, and lymphoma cancer cells.
Other research indicates that graviola can lower blood pressure, reduce heart rate, dilate blood vessels, and reduce spasms and convulsions. |
Main Actions
• kills cancer cells
• slows tumor growth
• kills bacteria
• kills parasites
• reduces blood pressure
• lowers heart rate
• dilates blood vessels
• sedates
Other Actions
• relieves depression
• reduces spasms
• kills viruses
• reduces fever
• expels worms
• stimulates digestion
• stops convulsions
Leaves
Infusion: One cup three times
Daily Tincture: 2-4 ml three times daily
Tablets/Capsules: 2 g three times daily
HERBAL PROPERTIES AND ACTIONS
Graviola is a small, upright evergreen tree, 5-6 m high, with large, glossy, dark green leaves. It produces a large, heart-shaped, edible fruit that is 15-20 cm in diameter and green in color, with white flesh inside. Graviola is indigenous to most of the warmest tropical areas in South and North America, including the Amazon. The fruit is sold in local markets in the tropics, where it is called graviola in Brazil, guanabana in Spanish-speaking countries, and soursop in the Unit ed States. The fruit pulp is excellent for making drinks and sherbets and, though slightly sour-acidic, can be eaten out of hand.
All parts of the graviola tree are used in natural medicine in the tropics, includ ing the bark, leaves, roots, fruit, and fruit seeds. Different properties and uses are attributed to the different parts of the tree. Generally, the fruit and fruit juice are taken for worms and parasites, to cool fevers, to increase mother's milk after childbirth, and as an astringent (drying agent) for diarrhea and dysentery. The crushed seeds are used against internal and external parasites, head lice, and worms. The bark, leaves, and roots are considered antispasmodic, hypoten- sive, and sedative, and a tea is made for various disorders toward those effects. Graviola has a long, rich history of use in herbal medicine as well as a lengthy recorded indigenous use. In the Peruvian Andes, a leaf tea is used for catarrh (inflammation of mucous membranes) and the crushed seed is used to kill parasites. In the Peruvian Amazon the bark, roots, and leaves are used for diabetes and as a sedative and antispasmodic. Indigenous tribes in Guyana use a leaf and/or bark tea as a sedative and heart tonic. In the Brazilian Amazon a leaf tea is used for liver problems, and the oil of the leaves and unripe fruit is mixed with olive oil and used externally for neuralgia, rheumatism, and arthri tis pain. In Jamaica, Haiti, and the West Indies, the fruit and/or fruit juice is used for fevers, parasites, and diarrhea; the bark or leaf is used as an antispas modic, sedative, and nervine for heart conditions, coughs, flu, difficult child birth, asthma, hypertension, and parasites.
Today, in the United States and Europe, graviola is sold as a popular adjunc- tive natural therapy for cancer. This use has stemmed from published research on graviola and its naturally occurring chemicals possessing anticancerous actions, rather than its established traditional uses in South America.
Many active compounds and chemicals have been found in graviola, as scientists have been studying its properties since the 1940s. Most of the research on graviola focuses on a novel set of chemicals called Annonaceous acetogenins. Graviola produces these natural compounds in its leaf and stem, bark, and fruit seeds. Three separate research groups have confirmed that these chemicals have significant antitumorous properties and selective toxicity against various types of cancer cells (without harming healthy cells). These groups have published eight clinical studies on their findings. 1" 8 Many of the acetogenins have demon strated selective toxicity to tumor cells at very low dosages—as little as 1 part per million. Four studies were published in 1998 which further specify the chemicals and acetogenins in graviola that are demonstrating the strongest anti-cancerous, antitumorous, and antiviral properties. 9" 12
Annonaceous acetogenins are only found in the Annonaceae family (to which graviola belongs). These chemicals in general have been documented with antitumorous, antiparasitic, insecticidal, and antimicrobial activities. 13 Mode of action studies in three separate laboratories have recently determined that these acetogenins are superb inhibitors of enzyme processes that are only found in the membranes of cancerous tumor cells. This is why they are toxic to cancer cells but have no toxicity to healthy cells. Purdue University, in West Lafayette, Indiana, has conducted a great deal of the research on the acetogenins, much of which has been funded by The National Cancer Institute and/or the National Institutes of Health (NIH). Thus far, Purdue University and/or its staff have filed at least nine U.S. and/or international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins.
In 1997, Purdue University published information with promising news that several of the Annonaceous acetogenins "not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells." 14 In several interviews after this information was publicized, the head pharmacologist in Purdue's research explained how this worked. As he explains it, cancer cells that survive chemotherapy can develop resistance to the agent originally used as well as to other, even unre lated, drugs. This phenomenon is called multi-drug resistance (MDR). One of the main ways that cancer cells develop resistance to chemotherapy drugs is by cre ating an intercellular pump, which is capable of pushing anticancer agents out of the cell before they can kill it. On average, only about two percent of the can cer cells in any given person might develop this pump—but they are the two percent that can eventually grow and expand to create multi-drug-resistant tumors. Some of the latest research on acetogenins reported that they were capable of shutting down these intercellular pumps, thereby killing multi-drug- resistant tumors. Purdue researchers reported that the acetogenins preferentially killed multi-drug-resistant cancer cells by blocking the transfer of ATP—the chief source of cellular energy—into them. 15
A tumor cell needs energy to grow and reproduce, and a great deal more to run its pump and expel attacking agents. By inhibiting energy to the cell, it can no longer run its pump. When acetogenins block ATP energy to the tumor cell over time, the cell no longer has enough energy to operate sustaining process es—and it dies. Normal cells seldom develop such a pump; therefore, they don't require large amounts of energy to run a pump and, generally, are not adversely affected by ATP inhibitors. Purdue researchers reported that fourteen different acetogenins tested thus far demonstrate potent ATP-blocking proper ties (including several found only in graviola). 15 They also reported that thir teen of these fourteen acetogenins tested were more potent against MDR breast cancer cells than all three of the standard drugs (adriamycin, vincristine, and vinblastine) they used as controls.
The Annonaceous acetogenins discovered in graviola thus far include: anno- catalin, annohexocin, annomonicin, annomontacin, annomuricatin A and B, annomuricin A through E, annomutacin, annonacin, annonacinone, annopen- tocin A through C, cis-annonacin, cis-corossolone, cohibin A through D, core- poxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A and B, gigantetrocin, gigantetrocin A and B, gigantetrocinone, gigantetronenin, gonio- thalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A through G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muri- catetrocin A and B muricatin D, muricatocin A through C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A through C, murihexol, muri- solin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I and IV, and xylomaticin.
In a 1976 plant screening program by the National Cancer Institute, graviola leaves and stem showed active toxiciry against cancer cells, and researchers have been following up on these findings since. 16 Thus far, specific aceto genins in graviola and/or extracts of graviola have been reported to be selec tively toxic in vitro to these types of tumor cells: lung carcinoma cell lines; 1' 3" 6
human breast solid tumor lines; 4 prostate adenocarcinoma; 9 pancreatic carcinoma cell lines; 1- 9' 12 colon adenocarcinoma cell lines; 1' 2' 12 liver cancer cell lines; 17" 20 human lymphoma cell lines; 21 and multi-drug-resistant human breast adenocarcinoma. 22 Researchers in Taiwan reported in 2003 that the main graviola acetogenin, annonacin, was highly toxic to ovarian, cervical, breast, bladder and skin cancer cell lines at very low dosages, saying "annonacin is a promising anti-cancer agent and worthy of further animal studies and, we would hope, clinical trials." 23
An interesting in vivo study was published in March of 2002 by researchers in Japan, who were studying various acetogenins found in several species of plants. First they inoculated mice with lung cancer cells. Then, one third re ceived nothing (the control group), one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreat ed control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6 percent reduction of tumor mass over the con trol group—but 50 percent of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibit ed by 57.9 percent—slightly better than adriamycin—and without toxicity. This led the researchers to summarize: "This suggested that annonacin was less toxic in mice. On considering the antitumor activity and toxicity, annonacin might be used as a lead to develop a potential anticancer agent." 24
Other studies over the years have validated some of graviola's other uses in herbal medicine. Several early studies demonstrated that the bark as well as the leaves had hypotensive, antispasmodic, anticonvulsant, vasodilator, smooth-muscle relaxant, and cardiodepressant activities in animals. 25' 26 Researchers verified graviola leaf's hypotensive properties in rats again in 1991. 27 Several studies over the years have demonstrated that leaf, bark, root, stem, and seed extracts of graviola are antibacterial in vitro against numer ous pathogens, 28" 30 and that the bark has antifungal properties. 30' 31 Graviola seeds demonstrated active antiparasitic properties in a 1991 study, which validated its long standing traditional use, 32 and a leaf extract showed to be active against malaria in two other studies (in 1990 and 1993). 33' 34 The leaves, root, and seeds of graviola demonstrated insecticidal properties, with the seeds demonstrating strong insecticidal activity in an early 1940 study. 35 In a 1997 clinical study, novel alkaloids found in graviola fruit exhibited antide- pressive effects in animals. 36
Cancer research is ongoing on these important Annona plants and plant chemicals, as several pharmaceutical companies and universities continue to research, test, patent, and attempt to synthesize these chemicals into new chemotherapeutic drugs. In fact, graviola seems to be following the same path as another well-known cancer drug—Taxol. From the time researchers first discovered an antitumorous effect in the bark of the pacific yew tree and a novel chemical called taxol was discovered in its bark, it took thirty years of research by numerous pharmaceutical companies, universities, and government agencies before the first PDA-approved Taxol drug was sold to a cancer patient (which was based on the natural taxol chemical they found in the tree bark).
With graviola, it has taken researchers almost ten years to successfully synthesize (chemically reproduce) the main antitumorous chemical, annonacin. These acetogenin chemicals have a unique waxy center and other unique molecular energy properties, which thwarted earlier attempts, and at least one major pharmaceutical company gave up in the process. Now that scientists have the ability to recreate this chemical and several other active acetogenins in the laboratory, the next step is to change the chemical just enough (without losing any of the antitumorous actions in the process) to become a novel chemical, which can be patented and turned into a new (patented) cancer drug. (Naturally occurring plant chemicals cannot be patented.) Thus far, scientists seem to be thwarted again—every time they change the chemical enough to be patentable, they lose much of the antitu morous actions. Like the development of taxol, it may well take government agencies like the National Cancer Institute and the National Institutes of Health to step forward and launch full-scale human cancer research on the synthesized unpatentable natural plant chemical (which will allow any phar maceutical company to develop a cancer drug utilizing the research, as happened with taxol) to be able to make this promising therapy available to cancer patients in a timely fashion.
In the meantime, many cancer patients and health practitioners are not waiting—they are adding the natural leaf and stem of graviola (with over forty documented naturally occurring acetogenins, including annonacin) as a complementary therapy to their cancer protocols. After all, graviola has had a long history of safe use as an herbal remedy for other conditions for many years, and research indicates that the antitumorous acetogenins are selectively toxic to just cancer cells and not healthy cells—and in miniscule amounts. While research confirms that these antitumorous acetogenins also occur in high amounts in the fruit seeds and roots of graviola, different alkaloid chem icals in the seeds and roots have shown some preliminary in vitro neurotoxic effects. 35 Researchers have suggested that these alkaloids might be linked to atypical Parkinson's disease in countries where the seeds are employed as a common herbal parasite remedy. 36 Therefore, using the seeds and root of graviola is not recommended at this time.
The therapeutic dosage of graviola leaf, (which offers just as high of an amount of acetogenins as the root and almost as much as the seed) is reported to be 2-3 g taken three or four times daily. Graviola products (capsules and tinc tures) are becoming more widely available in the U.S. market, and are now offered under several different manufacturer's labels in health food stores. As one of graviola's mechanisms of action is to deplete ATP energy to cancer cells, combining it with other supplements and natural products that increase or enhance cellular ATP may reduce the effect of graviola. The main supplement that increases ATP is a common antioxidant called Coenzyme Q10 and for this reason, it should be avoided when taking graviola.
Graviola is certainly a promising natural remedy and one that again emphasizes the importance of preserving our remaining rainforest ecosystems. Perhaps—if enough people believe that the possible cure for cancer truly is locked away in a rainforest plant—we will take the steps needed to protect our remaining rainforests from destruction. One researcher studying graviola summarized this idea eloquently: "At the time of preparation of this current review, over 350 Annonaceous acetogenins have been isolated from 37 species. Our preliminary efforts show that about 50%, of over 80 Annona ceous species screened, are significantly bioactive and are worthy of frac- tionation; thus, this class of compounds can be expected to continue to grow at an exponential rate in the future, provided that financial support for such research efforts can be found. With the demise of the world's tropical rain forests, such work is compelling before the great chemical diversity, con tained within these endangered species, is lost." 15
The therapeutic dosage is reported to be 2 g, three times daily, in capsules or tablets. A standard infusion (1 cup three times daily) or a 4:1 standard tincture (I-A ml three times daily) can be substituted if desired.
Graviola has demonstrated uterine stimulant activity in an animal study (rats) and should therefore not be used during pregnancy.
Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies and is contraindicated for people with low blood pressure. People taking antihypertensive drugs should check with their doctors before taking graviola and monitor their blood pressure accordingly (as med ications may need adjusting).
Graviola has demonstrated significant in vitro antimicrobial properties. Chronic, long-term use of this plant may lead to the death of friendly bacteria in the digestive tract due to its antimicrobial properties. Supplementing the diet with probiotics is advisable if this plant is used chronically.
One study with rats given a stem-bark extract intragastrically (at 100 mg/kg) reported an increase in dopamine, norepinephrine, and monomine oxidase activity, as well as an inhibition of serotonin release in stress-induced rats. 39
Alcohol extracts of graviola leaf showed no toxicity or side effects in mice at 100 mg/kg; however, at a dosage of 300 mg/kg, a reduction in explorative behavior and mild abdominal constrictions were observed. 40 If sedation or sleepiness occurs, reduce the amount used.
Drug Interactions None have been reported; however, graviola may potentiate antihypertensive and cardiac depressant drugs. See contraindications above.
Taking graviola in combination with Coenzyme Q 10 and other agents that increase cellular ATP energy may reduce the effects of graviola.
Uses
for abscesses, bronchitis, chest problems, cough, diabetes, diarrhea, dysentery, edema, fever, intestinal colic, intestinal parasites, liver problems, nervousness, neuralgia, pain, parasites, rheumatism, spasms, worms
for chills, fever, flu, indigestion, nervousness, palpitations, rash, spasms, skin disease, and as a sedative for childbirth, gallbladder problems, nervousness, and as a sedative and tranquilizer
for coughs, diarrhea, digestive sluggishness, fever, flu, heart conditions, lice, nerves, parasites, pain, pellagra, sores, spasms, weakness, wounds, and as a lactation aid and sedative
for asthma, fevers, heart conditions, hypertension, nervousness, parasites, spasms, water retention, weakness, worms, and as a lactation aid and sedative
for boils, coughs, diarrhea, dermatosis, hypertension, rheumatism, and to reduce bleeding for chest colds, diarrhea, dysentery, fever, ringworm, scurvy, and to reduce bleeding for diarrhea, dyspepsia, kidney, stomach ulcers, worms
for diabetes, diarrhea, dysentery, fever, hypertension, indigestion, inflammation, lice, liver disorders, parasites, spasms, tumors, ulcers (internal), and as a sedative
for blood cleansing, fainting, flu, high blood pressure, insomnia, palpitations, ringworms, and as a lactation aid
for cancer, depression, fungal infections, hypertension, intestinal parasites, tumors
for asthma, childbirth, diarrhea, hypertension, parasites, worms, and as a lactation aid
for arthritis, asthma, bile insufficiency, childbirth, cancer, diarrhea, dysentery, fever, heart problems, kidney problems, lice, liver disorders, malaria, pain, ringworm, scurvy, stomach problems, and as a lactation aid and sedative
Graviola
"In an 1976 plant screening program by the National Cancer Institute, the leaves and stem of Graviola showed active cytotoxicity against cancer cells and researchers have been following up on this research ever since.
Much of the research on Graviola focuses on a novel set of phytochemicals called annonaceous acetogenins. The potent antitumor, pesticidal and/or insect antifeedant properties of these annonaceous acetogenins have been reported and patented. Graviola produces these natural compounds in leaf, bark and twig tissues, and they have be documented to possess both highly anti-tumor and pesticidal properties.
Mode of action studies in three separate laboratories have recently determined that acetogenins are superb inhibitors of Complex I in mitochondrial electron transport systems from several organisms including tumors.
Research on various Annona species of plants has yielded many extremely potent acetogenins. Many of them have cytotoxicity with ED50 values as low as 10-9 ug/ml. Active compounds from Graviola and other Annona plants have been submitted to the NIH anti-AIDS screen by Purdue University and their work is continuing with a number of other active plant species in the Annona plant family.
Thus far, Purdue and/or it's staff have filed at least 9 U.S. and/or international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins.
Three separate research groups have isolated novel compounds in the seeds and leaves of Graviola which have demonstrated significant anti-tumorous, anticancerous and selective toxicity against various types of cancer cells, publishing 8 clinical studies on their findings.
One study demonstrated that an acetogenin in Graviola was selectively cytotoxic to colon adenocarcinoma cells in which it was 10,000 times the potency of adriamycin (a chemotherapy drug).
Cancer research is ongoing on Graviola, and four new studies have been published in 1998 which further narrow down the specific phytochemicals which are demonstrating the strongest anticancerous and antiviral properties.
Annonaceous acetogenins are only found in the Annonaceae family. In general, various annonaceous acetogenins have been documented with antitumor, antiparasitic, pesticidal, antiprotozoal, antifeedant, anthelmintic, and antimicrobial activities.
There has been much interest in the chemicals which have demonstrated potent antitumor properties and several research groups are trying to synthesize these chemicals for new chemotherapeutic drugs.
In a review of these natural chemicals in The Journal of Natural Products in 1999 they noted: "The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids.
Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms."
Another review in the Skaggs Scientific Report 1997-1998 states, "Annonaceous acetogenins, particularly those with adjacent bis-tetrahydrofuran (THF) rings, have remarkable cytotoxic, antitumor, antimalarial, immunosuppressive, pesticidal, and antifeedant activities.
Many of these fatty acid derivatives have similar carbon skeletons; their striking diversity originates mainly from the relative and absolute configuration of their various stereogenic oxygen functions."
Purdue University has conducted a great deal of research on annonaceaous acetogenins, much of which has been funded by The National Cancer Institute and/or the National Institute of Health. In one of their reviews titled Recent Advances in Annonaceous Acetogenins, they state: "Annonaceous acetogenins are waxy substances consisting of C32 or C34 long chain fatty acids which have been combined with a 2-propanol unit at C-2 to form a lactone.
They are only found in several genera of the plant family, Annonaceae. Their diverse bioactivities as antitumor, immunosuppressive, pesticidal, antiprotozoal, antifeedant, anthelmintic, and antimicrobial agents, have attracted more and more interest worldwide.
Recently, we reported that the Annonaceous acetogenins can selectively inhibit the growth of cancerous cells and also inhibit the growth of adriamycin resistant tumor cells. As more acetogenins have been isolated and additional cytotoxicity assays have been conducted, we have noticed that, although most of acetogenins have high potencies among several solid human tumor cell lines, some of the derivatives within the different structural types and some positional isomers showed remarkable selectivities among certain cell lines, e.g., against prostate cancer (PC-3).
We now understand the primary modes of action for the acetogenins. They are potent inhibitors of NADH: ubiquinone oxidoreductase, which is in an essential enzyme in complex I leading to oxidative phosphorylation in mitochondria. A recent report showed that they act directly at the ubiquinone-catalytic site(s) within complex I and in microbial glucose dehydrogenase.
They also inhibit the ubiquinone-linked NADH oxidase that is peculiar to the plasma membranes of cancerous cells."
In 1997, Purdue University published information with promising news that several of the Annonaceous acetogenins: "not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells."
In several interviews after this information was publicized, the head Purdue pharmacologist in Purdue's research explains that cancer cells that survive chemotherapy may develop resistance to the agent originally used against them as well as to other, even unrelated, drugs.
"The term multi-drug resistance (MDR) has been applied to this phenomenon," he says. He explains that such resistance develops in a small percentage of cancer cells when they develop a "P-glycoprotein mediated pump" capable of pushing anti-cancer agents out of the cell before they can kill it.
Normal cells seldom develop such a pump. "If having this pump was such a good deal, all cells would have it. But all cells don't," the Purdue researcher says. "In a given population of cancer cells in a person, maybe only 2% of the cancer cells possess this pump. But it's those 2% of cancer cells that eventually grow and expand to create drug-resistant tumors."
They go on to say that some studies have tried to bypass these pumps by keeping them busy with massive doses of other drugs, like the blood pressure agent verapamil. In this way, it was hoped that some of the anti-cancer drugs would enter the cell and destroy it. But this only caused potentially fatal side effects such as loss of blood pressure.
In the June issue of Cancer Letters, the Purdue researchers reported that the Annonaceous acetogenin, bullatacin, preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate, ATP -- the chief energy-carrying compound in the body.
"A multi-drug resistant cell requires a tremendous amount of energy to run the pump and extrude things out of the cell," Purdue head pharmacolgist says.
"By inhibiting ATP production, we're essentially pulling the plug on its energy source." But what about the effect on ATP in normal cells? "Normal cells and standard cancer cells may be able to minimize the effect of this compound because they don't require vast amounts of energy needed by the pump-running cells," the Purdue researcher says. "The resistant cell is using its extra energy for this pump as well as to grow, so it is really taxed for energy.
When we mess with the energy supply, it kills the cell!"
Original Source: Dr. Leslie Taylor, ND, Raintree Nutrition, Inc. and Square One Publishers,
Customer Service Raintree Nutrition, Inc. 3579 Hwy 50 East, Suite 222 Carson City, Nevada USA (775) 841-4142 (800) 780-5902 Fax: (775) 841-4022 Website: http://www.rain-tree.com
Richard Lund:
"We, like you, are not doctors, so we cannot dispense medical advice. But we do try to educate people about Paw Paw's actions to slow ATP production in abnormal cells in the body.
Our toll free number is 877-871-6262. The web address for sale of the Paw Paw twig extract is pawpawforhealth.com.
The material largely applies to Paw Paw as well as to Graviola. They both contain the Annonaceous acetogenins.
In fact, the one acetogenin mentioned, bullatacin, does not occur in Graviola. It was first isolated from Annona bullata by Dr. McLaughlin and has been found in Paw Paw as well as some of the other Annonaceous family, but not in Graviola."
Thanks to Anne Caputi** for the following information:
8/03 UPDATE:
Recently numbers of visitors to this site have been writing to me inquiring about the powerful rainforest herb, Graviola. I would like to clarify my experience and recommendations regarding this herb.
I have never used Graviola as a single bulk herb. I use a very high quality liquid herbal tincture which is a combination of Graviola and numbers of other rainforest herbs. This combination of herbs is specifically designed to enhance and potentiate the power of Graviola. Graviola has been shown to have an effect on cancer cells which can be of great benefit to someone who is fighting cancer.
Because it is so effective, it is important to supplement the use of graviola with herbs which support detoxification and protection of the major detoxyfing organs.
I use Gravizon, a comprehensive formula produced by The Amazon Herb Company. The main ingredient in Gravizon is graviola Graviola is a medium size shrub growing in the Amazonian jungle. The graviola tree produces a delicious fruit commonly called paw-paw, which is widely consumed by indigenous people.
Nearly 25 years ago it was discovered that the leaf of the graviola tree contained natural compounds having exceptional cytotoxic activity. In other words, they had a very strong ability to prevent abnormal cellular division.
In that sense, Gravizon is considered a unique product for immune support, assisting the immune system in cleaning abnormal tissue growth.
When the immune system works in this manner to "clean up" tissues, it must be able to easily reach the target tissue and the debris must be eliminated effectively. For this reason, in Gravizon, graviola is blended with Recovazon (another formula from Amazon Herb Company) that contains many herbs known for their ability to stimulate blood and lymphatic circulation's, Envirozon that assists liver functions, and Arcozon that assists immune functions.
In addition to these herbs, Gravizon also contains strong antioxidants that provide protection against free radicals. For example, cam camu, a small fruit the size of a large cherry that contains up to 4,000 times the amount of Vitamin C contained in on orange.
Also, sangre de drago, the sap of a tree that is nearly 90% oligomeric proanthocyanidins, the active component in grapeseed extract.
Therefore, Gravizon is a unique formula designed to provide unique immune support to assist the body in regaining and maintaining health.
March, 2003 update on Anne Caputi:
"I had my 6th follow-up MRI this morning. Next week is the one year anniversary of my brain surgery. Another perfectly clear scan!
Then I got my tumor markers. The lowest they have ever been in almost six years . I don't remember the first time we tested them, but as of last week, my CEA is 5.5, (normal is 0-4) and my CA27-29 is down this month, from 121 in February to 90 currently!
They really don't know what to make of me. I enjoy keeping this going.
Still, no one asks my secret."
**Anne Caputi is willing to receive and respond to email.
Contact her at acaputi@rcn.com
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