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What people say makes us excited::
Measles virus trained to hunt down cancer cells!:
[Health India]: Washington, Feb 3 : An international team of Mayo Clinic-led researchers has succeeded in devising a system which converts the measles virus into a therapeutic killer to hunt down and destroy cancer cells.
According to a study published in The Nature, the researchers harnessed the viral trait for attacking and commandeering cells, and then redirected the virus to attack diseased, rather than healthy cells.
Though the work was done on laboratory animals implanted with two kinds of human cancer cells, ovarian cancer and lymphoma, yet the concept has at last been proved in mice with human cancer tumors, and that's an essential step toward using this approach to expand and improve human treatments for a variety of cancers.
"When I saw the data, I was completely stunned. It's the sort of thing that, having worked on targeting viruses for about 15 years, I just couldn't believe that we'd finally got what we'd been hunting all that time," Stephen Russell, lead researcher and director of Mayo Clinic's Molecular Medicine Program, said.
"It's very clean, very clear targeting. Our results show that we've efficiently ablated (destroyed) the ability of the measles virus to interact with its two natural receptors. And they also show that we can take our pick as to what new receptor we target and send the virus after it," he added.
Using bioengineering techniques, the team reprogrammed the measles virus to seek a cancer cell to bind to instead of its natural binding partner. Then they invented a "molecular tag" that they attached to structures on the outside of the cancer- seeking measles virus. This tag is the key innovation of their work and central to the success of the team's investigation. It enables researchers to grow re-targeted measles virus on special "universal substrate cells" ,while at the same time conserving the viral component for targeting and destroying tumors.
"The virus goes where it's meant to go, and it destroys the tumors in a targeted way,''Russell explained.(ANI)
http://www.newkerala.com/news-daily/news/features.php?action=fullnews&id=68114
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