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A Real Breakthrough; New Formula,

What people say makes us excited::

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Vaccine using weakened malarial parasite to be tested soon:

[India News]: Ahmedabad, Jan 6 : A vaccine against malaria that has been found to protect mice when injected through bite of mosquitoes would be tested by US scientists soon.

"There is some element of naturally acquired immunity in relation to malaria, which shows that vaccine against this disease is possible, although so far this has been a difficult task," Stephen L Hoffman, Chief Executive and Scientific Officer of US company Sanaria, said at the 92nd session of the Indian Science Congress here last evening.

The vaccine has been produced by the company in association with a Maryland-based Malaria Research Centre, he said adding it uses the weakened malarial parasite. The vaccine is targeted against deadly falciparum malaria which affects the brain and has high mortality.

Malaria has a complex life cycle and in human beings it has several stages, Hoffman said added that the vaccine uses "sporozoite" stage of parasite when it enters the liver.

The trials would combine phase I and II in which the vaccine would be tested in 60 patients in a centre in Africa. The aim is to test protection levels achieved in humans after vaccination as also safety of the new vaccine, Hoffman said.

The study would take about a year. After this, phase III studies would be done, he said.

Previously, it has been shown that mice which are given this vaccine through mosquito bites are protected against the disease. Preliminary studies on the similar lines suggest that 94 per cent of people who were given the vaccine were protected for at least 10 months.

These studies have been carried over a period of 15 years, he said. PTI

 

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